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Jan 6, - Doctors usually perform a procedure called lateral internal sphincterotomy (LIS), which involves cutting a small portion of the anal sphincter muscle to reduce spasm and pain, and promote healing. Studies have found that for chronic fissure, surgery is much more effective than any medical treatment. Jan 6, - Anal fissure — Comprehensive overview covers symptoms, causes, treatment of An anal fissure that fails to heal within six weeks is considered (internal anal sphincter), making it more difficult for your anal fissure to heal.